We are developing innovative software tools that can faithfully simulate the behaviour of biochemical networks, focussing on programmed cell death (apoptosis) and growth factor activated kinase (MAPK). Both networks are at the focus of current drug discovery efforts in important disease areas including cancer, arteriosclerosis, stroke, heart disease, chronic inflammatory and degenerative diseases. The tools we are developing will facilitate basic research by enabling a deeper understanding of the effects of mutations, and applied research by helping to predict drug effects. A strategic aspect of this work is the continuous cross check between modelling and real experimental data.
Associated with this project are 3 Industrial PhD studentships funded by Scottish Enterprise.
This interdisciplinary project involves bioinformatics, biochemistry and computer science, with contributions from IBM and Definiens.
Funding is for 3 researchers over 4 years at a total of £940,000 provided by the Department of Trade and Industry UK, under the Beacon scheme - see www.beaconprojects.org.uk.
The project was launched on 20 November 2002 at an event organised by the DTI.
Project presentation slideshow: HTML, PDF
Investigators:
Researchers:
Richard Orton - Bioinformatician
Oliver Sturm - Biologist
Scottish Enterprise PhD Industrial Studentships : University of Glasgow, CXR
Biosciences and Cyclacel.
Two PhD Industrial Studentiships are being held at the University of Glasgow,
funded by Scottish Enterprise through
their
Biotechnology programme.
These studentships are being undertaken in collaboration with the
Department of Trade and Industry funded
BPS project.
More information on the student projects can be found at
www.brc.dcs.gla.ac.uk/projects/scotentstudenships
Contact: Professor David Gilbert, drg@brc.dcs.gla.ac.uk
